Human papillomavirus and neoplasia
Department of Ophthalmology, Grigore T.
E-mail: moc. We report the human papillomavirus and neoplasia of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.
The method used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence.
Keywords: Conjunctiva, eye, human papillomavirus human papillomavirus and neoplasia, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus Human papillomavirus and neoplasia infection is strongly associated with anogenital tumors human papillomavirus and neoplasia, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.
The association between HPV infection and eye tumors is little explored territory.
Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.
Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half.
He has been treated for the last 2 cheloo nimeni altu with dexamethasone eye human papillomavirus and neoplasia for scleritis by another ophthalmologist. The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses.
All other ophthalmological findings were normal. Conjunctival culture was performed before surgery, and no bacterial infection was found.
Material and method: Sixty patients were included in our study. All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3. Results: 7 of our cases were benign
The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes. The limbic lesion was removed surgically with 2 mm margin of normal tissue and diathermy human papillomavirus and neoplasia the adjacent sclera was done.
At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.
Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.
И еще - чтобы вы узнали о том, что он умеет читать человеческую речь по губам и будет рад ответить на любой ваш вопрос. - Как это. - удивился кое-кто из солдат. Тем временем недовольный капитан Пиоджи стоял в сторонке, передавая по ходу развития событий отчет полковнику в Нью-Йорк.
- Да, сэр, - говорил он, - у него на голове полосы.