Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix, Variantele genice ale Interleukinei 1β -511 C>T şi neoplazia intraepitelială cervicală

Întrucât cancerul cervical are o lungă perioadă de evoluţie sub forma unor leziuni precursoare, depistarea şi tratarea acestora reprezintă o măsură extrem de eficientă de prevenire a cancerului de col invaziv. Aplicarea standardelor, principiilor şi aspectelor fundamentale ale conduitei terapeutice va conduce la creşterea calităţii actului medical şi reducerea variaţiilor în practica medicală.

View in PDF Number of views: 2 Nowadays, more and more evidence points out to the interrelationship between intestinal microbiota and cardiovascular diseases. Gut microbiota is composed of a large number of microorganisms that live in the human gut and are involved in many physiological processes.

Changes in the composition and activity of intestinal microbiota may lead or may accelerate the evolution of some cardiovascular diseases.

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Alterations in the composition of gut microbiota will induce dysbiosis, causing inflammation and initiating the development of cardiovascular diseases. These alterations may be secondary to intestinal infections, exposure to some environmental factors, changes in dietary habits, high stress, use of antibiotics.

Studies have shown that gut microbiota is composed of six families, the Firmicutes, Bacteroidetes, Proteobacteria, Actino-bacteria, Fusobacteria, and Verrucomicrobia phyla1.

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These microorganisms are involved in the immune processes of the host, the fight against the pathogenic microorganisms and also in maintaining the integrity of intestinal barriers. Coronary heart disease and arterial hypertension are chronic diseases with a high prevalence.

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Some studies have demonstrated a link between the composition of gut microbiota and the increased risk of atherosclerosis, which is the main cause of coronary heart disease2,3. These studies have identified different species of bacteria, both in the gut and in the atheromatous plaques, suggesting that gut is a source of atherogenic bacteria2,3.

The mechanisms by which these bacteria can initiate the atherosclerotic process or in some cases protect against it are still unknown.

Rotar, Florin V. Interleukin 1β is a proinflammatory cytokine that plays a critical role in chronic inflammation and carcinogenesis.

Trimethylamine N-oxide TMAO is a microbial metabolite that was studied for its effects on cardiovascular diseases after the discovery of a positive correlation between the serum level of TMAO and the atherosclerotic plaque area. This correlation was partially explained by the role that TMAO plays in the inhibition of reverse cholesterol transport and the accumulation of macrophage cholesterol4,5.

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One study has found that the TMAO level in patients with an acute coronary syndrome is an independent predictor of short-term and long-term major adverse cardiac events6. The implication of gut microbiota in arterial hypertension has been demonstrated by animal studies7,8.

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Adnan et al have shown that the blood pressure can be influenced by the exchange of gut microbiota between spontaneously hypertensive rats and Wistar-Kyoto rats7. The ratio of Firmicutes and Bacteroidetes is considered specific for intestinal dysbiosis9.

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In animal studies, the alteration of this ratio correlated with arterial hypertension, suggesting that gut microbiota could be a potential target of future antihypertensive therapies9. Heart failure is the final stage of evolution of the majority of cardiovascular diseases, with high mortality rates. One study has comparatively analyzed the bacteria and fungi in the feces of patients with heart failure with those of healthy controls and demonstrated that patients with chronic heart failure have more pathogenic bacteria Moreover, some species, like Candida, Shigella, and Campylobacter, were positively correlated with the severity of the heart failure Patients with heart failure, with decreased cancer de colon metastasis higado output, have gastrointestinal mucosa congestion and ischemia, with subsequent alterations in the composition of gut microflora and also intestinal functions.

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These alterations will lead to bacterial translocation, the release of endotoxins in the circulation, promoting a systemic inflammatory response. Some authors suggested that TMAO can be used as a biomarker for prognosis stratification in patients with heart failure11, although the exact mechanisms of increased levels of TMAO in patients with heart failure are still unknown.

Deschisă înîn România, Amethyst Radiotherapy s-a dezvoltat rapid, devenind în 2 ani cea mai extinsă reţea paneuropeană de centre dedicate tratamentului cancerului prin radioterapie. În prezent, reţeaua Amethyst are 6 clinici deschise în 4 ţări, cumulând 10 acceleratoare liniare şi 4 echipamente de brahiterapie. La nivel european, printre cele mai frecvente tipuri de cancer tratate în cadrul Amethyst Radiotherapy se numără cancerul de sân, urmat de cel de prostată şi plămâni. În România, la acestea se adaugă tumorile la nivelul colului uterin şi ORL.

Other gut microbiota metabolites, p-cresyl sulfate and phenylacetylglutamine, have been suggested by some studies to be involved in the appearance of cardiovascular diseases12, Based on the above findings, the future cardiovascular therapies may include gut microbiota and their metabolites as potential targets.