Colorectal cancer during pregnancy

Metastatic cancer colon survival rate. Cancerul colorectal în sarcină

Anca Zgură, Laurenţia Galeş, Prof. Breast, ovarian, and cervical cancer are the most common cancers diagnosed during pregnancy. The manifestations encountered in colorectal cancer, such as abdominal pain, constipation, vomiting, nausea, rectal bleeding and altered bowel movements, are also found in normal pregnancy.

In this paper, we present a case of colorectal cancer with hepatic metastasis diagnosed in a year-old preganant woman IIG, 1Pat 32 weeks of pregnancy. Keywords pregnancy, colorectal cancer, metastasis, teratogencity, chemotherapy Rezumat Incidenţa cancerului colorectal în timpul sarcinii este mică, de un metastatic cancer colon survival rate la 1.

Cancerul colorectal în sarcină

Cancerul mamar, ovarian şi cel cervical sunt cele mai frecvente tipuri de cancer diagnosticate în timpul sarcinii. Manifestările întâlnite în cancerul colorectal, precum dureri abdominale, constipaţie, vărsături, greaţă, sângerări rectale şi tulburări intestinale, se întâlnesc şi în timpul sarcinii normale, făcând dificilă diagnosticarea pe metastatic cancer colon survival rate  sarcinii.

În această lucrare vă prezentăm cazul unei paciente de 36 de ani IIG, 1Pîn săptămâna a a de sarcină, diagnosticată cu cancer colorectal, prezentând şi metastaze hepatice. Cuvinte cheie cancer colorectal metastaze teratogenitate chimioterapie Introduction The incidence of colorectal cancer during pregnancy is reduced, being estimated at approximately one in every preganancies Breast, ovarian and cervical cancer are the most common cancers diagnosed during pregnancy 2.

The manifestations encountered in colorectal cancer, such as abdominal pain, constipation, vomiting, nausea, rectal bleeding and altered bowel movements, are also found in normal pregnancy 5.

Most of the colorectal cancers are missed and are diagnosed in advanced stages. Using the antineoplastic agents in a pregnant patient is a difficult decision, with many of safety and efficacy implications 6. The treatment plan depends on the desire of the pregnant woman, the stage of the disease, the possible teratogenic effects of the antineoplastic agents and metastatic cancer colon survival rate We present in this paper a case of colorectal cancer with hepatic metastasis diagnosed in a patient at 32 weeks of pregnancy.

Figure 1. She also had constipation and anemia.

Colorectal cancer during pregnancy

She was initially evaluated by her gynecologist, who suggested a second opinion from a gastroenterologist, who performed an abdominal and pelvic IRM. The abdominal and pelvic IRM evaluation revealed global hepatomegaly mm cranio caudal right lobe, 97 mm antero-posterior left lobeand more lobular contour space replacement formation. The CT scan of the thorax was without secondary pulmonary determinations.

metastatic cancer colon survival rate

There was no family history of cancer. The physical examination at the time was unremarkable, except for normal signs of pregnancy.

The patient was anemic at the time of presentation, the hemoglobin level was 9.

Studiu clinic şi statistic în cancerul colorectal

After the imagistic and biological evaluation, she was refered to a surgeon, who thought that her pregnancy would make difficult to receive prompt adjuvant therapy. The patient was only week pregnant at the time of metastatic cancer colon survival rate.

A caesarean section was performed, resulting in the birth of a premature baby, weighing g, who received an Apgar score of 9. During the same operation, a left hemicolectomy and right oophorectomy were also performed. The histopatological raport revealed a moderate adenocarcinoma G2six nodes were examinated, but only two were positive. The histopatological examination of the ovary showed metastasis of moderate adenocarcinoma Krukenberg ovary. Before deciding on the initiation of chemotherapy, the patient experienced altered generalized status, medium ascites, pleurisy and gambling edema.

She received a cycle of adjuvant metastatic cancer colon survival rate consisting of cetuximab mg. The patient tolerated the therapy with supportive treatment and minimal hematologic and non-hematologic toxicities. After one month, we changed the metastatic cancer colon survival rate cycle with cetuximab, oxaliplatin and 5-FU, metastatic cancer colon survival rate to the improvement of the general metastatic cancer colon survival rate.

A follow-up CT scan after three months showed evolution in mild numerical regression of metastatic cancer colon survival rate lesions. The metastatic cancer colon survival rate was maintained. Fine fluid blade in dimensional regression.

Cancerul colorectal în sarcină

Without bone metastases. The adjuvant chemotherapy combined with targeted therapy using cetuximab has been considered for the patient in order to eradicate the metastatic disease. Discussion Despite the metastatic cancer colon survival rate incidence rate of 0. Colorectal cancer is among the eight most common malignancies in pregnancy 2. Colorectal cancer in pregnancy represents a serious situation, and there are many challenging issues regarding the diagnosis and management in pregnancy.

Because the signs and simptoms are similar in pregnancy and colorectal cancer, the colorectal cancer can be concealed In our patient, the abdominal pain was misdiagnosed as a sign and simptom of a normal pregnancy. There are limitations and contraindications for using imaging tests during pregnancy.

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IRM remains relatively safe in pregnancy and the best option to evaluate the colorectal cancer. Serum CEA is an important test used in the evaluation of patients with colorectal cancer CEA levels during pregnancy may be elevated and can be used for monitoring the response of the treatment 15, Due to the fact that colorectal cancer is encoutered in the eldery and rarerly in young patients, it is assumed that there are a number of predisposing factors, metastatic cancer colon survival rate as Lynch syndrome, Peutz-Jeghers syndrome and inflammatory bowel disease Another challenging issue is the treatment, which should be started as early for the mother, and is based on the gestational age and tumor stage.

If diagnosis occurs during the first trimester of pregnancy, it may be expected until the fetus becomes viable, but with significant tumor progression 18, If the diagnosis occurs after the 20th week of pregnancy, colon resection may be delayed.

Chemotheray is safer in the second and third trimesters, when organogenesis is complete Effet papillomavirus chez lhomme are no human data for the effect of cetuximab in pregnancy The ovarian metastatic disease from colorectal cancer is another challenge.

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The incidence of ovarian metastases from colorectal cancer is higher in pregnant women. The survival of the pregnant woman with ovarian metastases is poor. Nesbitt et al. There are no fetal risk due to the malignancy itself, even in metastasis cases. The pregnant woman with colorectal cancer has a poor prognosis. A review of 15 cases  revealed that all patients with colorectal cancer presented in stage IV, and these patients died in 12 months after delivery Conclusions Colorectal cancer in pregnancy represents a diagnostic and therapeutic challenge.

Because the signs and simptoms are similar in pregnancy and colorectal cancer, the diagnosis of colorectal cancer is often delayed.

metastatic cancer colon survival rate

The therapeutic decison for a pregnant patient with colorectal cancer should involve a multidisciplinary team, and there must be taken into account the life of the unborn child and the survival of the mother. Conflict of interests: The metastatic cancer colon survival rate declare no conflict of interests.

Cancerul colorectal în sarcină

Carcinoma of metastatic cancer colon survival rate colon associated with pregnancy: report of a case. Dis Colon Rectum. Colorectal cancer discovered during pregnancy. J Gynecol Obstet et Biol Reprod. Cancer and pregnancy: an overview for obstetricians and gynecologists. Am J Obstet Gynecol. Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer?

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Eur J Cancer. Cancer chemotherapy and pregnancy. J Obstet Gynaecol Can. Cardonick E, Iacobucci A.

În unele cazuri, cancerele de colon pot cauza sângerări la nivelul tractului digesttiv, ceea ce duce la apariţia sângelui în fecale sau fecale de culoare închisă. Uneori cancerul poate bloca colonul, numită obstrucţie intestinală. Aceasta se manifestă prin: dureri puternice abdominale, balonare, constipaţie şi senzaţie constantă de rău. Obstrucţia intestinală este o urgenţă medicală.

Use of chemotherapy during human pregnancy. Lancet Oncol.

Cancer de colon - Tot ce trebuie să ştii | Cancer

Cancer chemotherapeutic agents as human teratogens. Chemotherapy during pregnancy. Curr Opin Oncol. Antineoplastic drugs.

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Drugs During Pregnancy and Lactation: treatment options and risk assessment. Amsterdam: Academic Press; ; — Management of rectal cancer in pregnant women. Bull Cancer. Mechery J, Ikhena SE.

Cancer of the descending colon during pregnancy. J Obstet Gynaecol. Colorectal cancer presenting with uncommon soft tissue invasion during pregnancy.

Acta Obstet Gynecol Scand. Gastroenterol Clini Biol. Colecchia G, Nardi M. Colorectal cancer in pregnancy. A case report.

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G Chir. Colon and rectal cancer in pregnancy. Cappell MS. Gastrointestinal endoscopy in high-risk patients. Dig Dis. Brent RL. The effect of embryonic and fetal exposure to X-ray, microwaves, and ultrasound: counseling the pregnant and nonpregnant patient about these metastatic cancer colon survival rate.

Semin Oncol. Prospective evaluation of different diagnostic techniques for the detection of liver metastases at time of primary resection of colorectal carcinoma. Eur J Surg. Use of magnetic resonance imaging in pregnancy to diagnosis intussusception induced by colonic cancer. Obstet Gynecol. Estrogen and progesterone receptors in colon tumors. Am J Clin Pathol. The Treatment of colorectal cancer during pregnancy: cytotoxic chemotherapy and targeted therapy challenges.

Colorectal Carcinoma in Pregnancy. Arch Surg.

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Jeppesen JB, Østerlind K. Successful twin pregnancy outcome after in utero exposure to FOLFOX for metastatic colon cancer: A case report and review of the literature.