Hpv squamous cell carcinoma tongue. Tratamentul carcinoamelor de planşeu oral anterior
Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users. Conclusions: The genotyping method was validated according to kit instructions.
Frequently, a mandible resection is required in order to obtain safe oncologic margins. The prognosis is good, with a higher overall survival rate than in other oral malignancies. Keywords carcinoma, floor of the mouth, mandible resection, neck dissection Rezumat Cu o prevalenţă inferioară tumorilor maligne ale limbii, tumorile maligne de planşeu anterior impun o abordare chirurgicală la fel de radicală, cu o margine de siguranţă mare şi cu managementul problemelor de la nivelul gâtului. Datorită localizării lor anterioare, sunt mai uşor de diagnosticat, iar pacientul se prezintă şi în stadii incipiente, nu doar în stadii tardive. Frecvent, este necesară rezecţia mandibulei, pentru hpv squamous cell carcinoma tongue obţine margini de siguranţă oncologică.
To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples. Ferlay J, Soerjomataram I hpv squamous cell carcinoma tongue al.
Comprehensive control of human papillomavirus infections and related diseases. Venuti A, Paolini F. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas.
Ursu RG, Danciu M et al. Virol J. Human papillomavirus prevalence in invasive laryngeal cancer in the United States.
Treatment of anterior floor of the mouth carcinomas
Shanesmith R, Allen RA et al. Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cell carcinomas.
The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of hpv squamous cell carcinoma tongue therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome.
HPV genotype distribution in oral and oropharyngeal squamous cell carcinoma using seven in vitro amplification assays. Garnaes E, Kiss K et al.
A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, the largest registry-based study to date. Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions.
Westra WH. Heiduschka G, Grah A et al. Masterson L, Moualed D et al.
Squamous cell carcinoma survivor on the importance of the HPV vaccine
Hpv squamous cell carcinoma tongue treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systema-tic review and meta-analysis of current clinical trials.