Hepatocellular cancer mutation
hepatocellular cancer mutation Some of the individual studies have tried to find the optimal combination of chemotherapy with TKIs. Nowadays, molecular biology helps clinicians to better understand the role of EGFR gene.
In conclusion, preclinical studies and well-designed randomized trials, including both continuous and intercalated EGFR-TKIs plus chemotherapy combinations, in first- and second-line therapy, will obtain better evidence in these settings. The improvements in the technology for detecting gene mutations resulted in the discovery of some novel mutations in EGFR that have been reported to be sensitive to TKIs, such as p.
VA, p. TA, p. SP and p. The role of EGFR should be evaluated in more detail in prospectively designed researches.
We estimate that the combination of TKIs and chemotherapy could be an alternative option in the treatment of advanced hepatocellular cancer mutation cell lung cancer NSCLC. Keywords tyrosine kinase inhibitors, chemotherapy, advanced non-small cell lung cancer Rezumat Această recenzie încearcă să analizeze câteva studii şi metaanalize ale inhibitorilor de tirozin-kinază TKI în combinaţie cu chimioterapia. Une studii individuale au încercat să descopere combinaţia optimă de chimioterapie cu TKI.
În concluzie, studiile preclinice şi studiile bine concepute randomizate, incluzând atât combinaţiile EGFR-TKI continue şi intercalate, cât hepatocellular cancer mutation combinaţiile de chimioterapie, în terapia de primă şi a doua linie, vor oferi dovezi mai bune în acest context. Îmbunătăţirile tehnologiei pentru detectarea mutaţiilor genetice au ca rezultat descoperirea unor mutaţii noi în EGFR care s-au raportat a fi sensibile la TKI, cum ar fi p.
SP şi p. Rolul EGFR ar trebui evaluat în detaliu, în cercetări prospective. Estimăm că o combinaţie dintre TKI şi chimioterapie ar putea fi o opţiune alternativă în tratamentul cancerului pulmonar fără celule mici NSCLC avansat. In this short review, I want to present again the issue of the association between tyrosine kinase inhibitors TKIs and chemotherapy in advanced non-small cell lung cancer NSCLC.
Therefore, randomized trials that compared this combined regimen with chemotherapy or EGFR-TKIs monotherapy were included for a meta-analysis performed in There were used published hazard ratios HRsif available, or derived-treatment estimates from other survival data. Pooled estimates of treatment efficacy of the combined regimen in the entire unselected population and selected patients by EGFR-mutation status and smoking hepatocellular cancer mutation were calculated.
Eight trials eventually entered into this meta-analysis, including patients. Unfortunately, the combined regimen had no significant impact on overall survival, irrespective of ethnicity, dose schedules or EGFR-mutation status.
Grants — Institute of Biochemistry of the Romanian Academy
Another meta-analysis was done, including nine randomized controlled trials, with a total of patients included. The combination of chemotherapy and erlotinib is a viable treatment hepatocellular cancer mutation for patients with NSCLC, especially for patients who have never smoked and patients hepatocellular cancer mutation EGFR mutation-positive disease. In addition, intercalated administration is an effective combinatorial strategy 3.
Another attempt to resolve this issue what causes eyelid papilloma TKIs and chemotherapy combination was the review published in Sim et al. There were a total of 35 studies conducted between andevaluating 12, participants, from different countries, including North America, Europe and Asia.
This review showed that patients with advanced lung cancer did not live longer when treated hepatocellular cancer mutation gefitinib, when compared with no other treatment or chemotherapy. In patients whose lung cancer worsened after the initial therapy, gefitinib may prolong the time before the parazi?ii 2019 progresses further, but only hepatocellular cancer mutation a selected group of patients of Asian ethnicity or with EGFR mutations.
Combining gefitinib with hepatocellular cancer mutation probably increases the interval to cancer progression over either gefitinib, or chemotherapy alone. For Hepatocellular cancer mutation positive patients who are stable after chemotherapy, ongoing gefitinib has been shown to improve survival when compared to placebo.
Severe side effects — such as low red and white blood cell counts and nerve symptoms — occurred more frequently in patients with chemotherapy compared to those with gefitinib.
The side effects caused by gefitinib included skin rash, diarrhoea and liver dysfunction. The quality of life may be improved in favour of gefitinib when compared with chemotherapy.
The authors concluded that combining gefitinib with chemotherapy appears to be superior in improving progression-free survival to either gefitinib or chemotherapy alone; however, further data and phase III studies in these settings are required hepatocellular cancer mutation. To explain the behaviour of the tumors response to epidermal growth factor receptor EGFR inhibitors and hepatocellular cancer mutation, when they are associated, there were hepatocellular cancer mutation some basic studies.
In one of this study 5hepatocellular cancer mutation aim was to detect the EGFR gene type at pre- and post-chemotherapy, in order to evaluate the impact of platinum-based chemotherapy on EGFR gene mutations and to provide a theoretical foundation for clinical treatment.
Wang et al. The outcomes were analyzed with SPSS Out of the 40 patients, 38 were included in the analysis.
An EGFR gene mutation was detected in 17 cases The EGFR gene type was consistent in 26 hepatocellular cancer mutation Among the 12 discordant cases, 5 cases changed from mutant type to wild type, while 7 cases changed from wild type to mutant type.
The conclusion was that platinum-based chemotherapy may change the serum EGFR gene type in advanced lung adenocarcinoma 5.
However, analyzing relevant research of the past 20 years, researchers found that the prognostic and predictive value of EGFR mutation status in NSCLC remains uncertain, and it is difficult to understand the precise mechanism by which cytotoxic agents influence EGFR-mutant and wild-type tumors differently.
With improvements in technology for detecting gene mutations, some novel mutations in EGFR have been reported to be sensitive to TKIs, such as p. The role of EGFR should be evaluated in more detail in prospectively designed research, so that we can have a deeper understanding of the association of EGFR mutation with the curative effect and survival benefit of chemotherapy in the future 6.
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An interesting study was published in Augustin the Journal of Clinical Oncology, by Cheng and colleagues. The study was analyzed by Antonio Rossi. The primary endpoint was progression-free survival, while secondary endpoints were TTP, overall survival, ORR, duration of response and toxicity.
The median progression-free survival was The median TTP was The analyses of all these outcomes in the main subgroups were consistent with the intention-to-treat results. Overall survival was still immature.
The authors concluded that the combination of pemetrexed and continuous gefitinib may offer EGFR mutation-positive patients a new treatment option compared with the current standard of care 7. A common deletion polymorphism within B-cell chronic lymphocytic leukemia-lymphoma like 11 gene BIM was studied and deemed to be a genetic cause leading to compromised kinase inhibitor therapeutic efficacy in cancer individuals.
Hou-Qun Ying et al. Sixty-five patients were enrolled. Further prospective studies are needed to validate these findings 9. Analyzing hepatocellular cancer mutation studies, it can be concluded that the association of TKIs and chemotherapy is not yet well defined, although many discoveries have been made, especially about molecular genetics, that have led to a more in-depth understanding of the possibilities of combining these therapies.
Conflict of interests: The author declares no conflict of interests. Bibliografie Grigorescu AC. World Journal of Research and Review. A comparison of gefitinib with no therapy or chemotherapy for non-small cell lung cancer. Cochrane Database of Systematic Reviews.
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DOI: Effect of platinum-based chemotherapy on EGFR gene mutation status in lung adenocarcinoma. Medicine Baltimore. Fang S, Wang Z.
EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer. Drug Des Devel Ther. Rossi A. Translational Cancer Research. The effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy.
Sci Rep. Lung Cancer.