Associated Data

Pancreatic cancer cell line. Cancerul pancreatic

Received Mar 9; Accepted Apr 8. Copyright © Chi-Ming Lee et al.

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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Associated Data Supplementary Materials S1. The error bars indicate standard error of the average.

Ristoiu, Violeta

Significance was determined by the Student t-test. All animals were humanely sacrificed pancreatic cancer cell line 4 weeks of monitoring due to the excessive tumor burden.

However, radiation-induced tumor cell death is limited by a number of factors, including the adverse response of the tumor microenvironment to the treatment and either intrinsic or acquired mechanisms of evasive resistance, and the existence of cancer stem cells CSCs.

Introduction Hepatocelluar carcinoma HCC represents one of the most common cancer types in the world.

Cancerul pancreatic

The standard treatment options for HCC often involve radiation- and chemo-therapy. Despite advances in the detection and treatment of the disease, mortality rate remains high because current therapies are limited by the emergence of radiation- and chemo-therapy-resistant cancer cells.

Elemente de anatomie si fiziologie by Violeta Ristoiu Book 2 editions published between and in Romanian and held by 3 WorldCat member libraries worldwide Lucrări practice de fiziologie animală by Violeta Ristoiu Book 1 edition published in in Romanian and held by 2 WorldCat member libraries worldwide Introducere în neurobiologia moleculară by Zach W Hall Book 1 edition published in in Romanian and held by 1 WorldCat member library worldwide Noţiuni de anatomie şi fiziologie by Maria Luiza Flonta Book 1 edition published in in Romanian and held by 1 WorldCat member library worldwide N-glycosylation of the transient receptor potential melastatin 8 channel is altered in pancreatic cancer cells 1 edition published in in English and held by 1 WorldCat member library worldwide Transient receptor potential melastatin 8 TRPM8a membrane ion channel, is activated by thermal and chemical stimuli. In pancreatic ductal adenocarcinoma, TRPM8 is required for cell migration, proliferation, and senescence pancreatic cancer cell line is associated with tumor size and pancreatic ductal adenocarcinoma stages. Although the underlying mechanisms of these processes have yet to be described, this cation-permeable channel has been proposed as an oncological target.

Existing radiation-therapies against HCC are usually developed against the bulk of the tumor mass, where although they are able to initially shrink the size of the tumor, they fail to eradicate the lesion in full, thus resulting in disease relapse.

Recently, HCC progression has been thought to be driven by cancer stem cells CSC through their capacity for self-renewal, production of heterogeneous progeny, and resistance to radiation-therapy and to limitlessly divide. Therefore, clarification of the radioresistance mechanism is essential for developing novel therapeutic modalities to sensitize hepatoma cells to radiation and improve patient survival.

CSCs are a subpopulation of tumors that are responsible for tumor maintenance and spreading.

Pancreatic cancer

These cells are characterized to possess unlimited proliferation potential, self-renewal ability, and differentiation capability to generate progenies pancreatic cancer cell line constitute the major tumor population [ 2 ].

The existence of CSCs has been described in a variety of hematologic and solid tumors including those of the breast, brain, colon, pancreas, lung, liver, and esophagus. CSCs are resistant to many current cancer treatments, including chemo- and radiation therapy [ 3 ]. In addition to driving tumorigenesis, CSCs pancreatic cancer cell line contribute to distant metastasis and disease relapse [ 4 ].

This suggests that the standard interventions, while killing the bulk of tumor cells, may ultimately fail because they do not eliminate CSCs but represent a selection pressure for CSCs. Since CSCs share similarities with stem cells, stem cell-associated surface markers have been used to identify and isolate CSCs in vitro.

In addition, CSCs can form spherical colonies in suspension cultures characterized and termed tumorspheres.

Importantly, isolated CSCs exhibit increased resistance to chemotherapeutic agent and ionizing radiation [ 2 ]. Therefore, CSCs have become an important target for drug development. Pterostilbene has attracted much attention pancreatic cancer cell line it has been demonstrated to have both chemopreventive activity and tumor-killing effects similar to those of resveratrol. For instance, pterostilbene was indicated to induce cell cycle arrest and apoptosis in a variety of cancer cell lines including lung, liver, breast, and pancreas [ 7 ].

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Recently, it has been reported that pterostilbene prevents azoxymethane- AOM- induced colon tumorigenesis in mice via suppressing cancer cell proliferation and the induction of apoptotic pancreatic cancer cell line [ 8 ].

In addition, several pharmacological properties of pterostilbene make it an ideal anticancer agent for development. Structurally, pterostilbene contains two methoxy groups and one hydroxyl group as compared to those of resveratrol which has three hydroxyl groups.

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The two methoxy groups substantially increase the lipophilicity and oral absorption of pterostilbene leading to a higher potential for cellular uptake. Furthermore, pterostilbene's half-life is also seven times longer than resveratrol, min versus 14 min [ 10 ].

Collectively, pterostilbene possesses many desired anticancer properties for the development as potential clinical agent.

Materials and Methods 2. Materials Pterostilbene 3,5-dimethoxyhydroxystilbene, Pterostilbene was dissolved in DMSO and further diluted in sterile culture medium immediately prior papiloma fibroepitelial histologia use.