Hpv cancer progression. Infecţia cu virusul papiloma uman şi strategii de implementare a imunizării
The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of hpv cancer progression tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of hpv cancer progression responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately hpv cancer progression among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement cancerul si zaharul the prevention of HPV oncoproteins action, with benefits on the outcome. A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide hpv cancer progression better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact.
This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be hpv cancer progression according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions. The immunization rates for Human papillomavirus are generally lower than for other types of vaccines, and further implementation of appropriate strategies is still needed.
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Cell adhesion system and human cancer morphogenesis. Cancer Sci ; HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology ; 1 Tumor biomarkers in cervical cancer: focus on Ki proliferation factor and E-cadherin expression.
Орел продолжал приводить факты и цифры о городе октопауков, но Николь думала о другом. - А Арчи жил. - спросила она, прерывая энциклопедический монолог своего спутника. - Или Синий Доктор, или кто-то из тех октопауков, с которыми hpv cancer progression встречалась. - Нет, - ответил Орел.
Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative hpv cancer progression indicators in cervical squamous cell carcinoma.
Hum Pathol ;